The present study was designed to investigate the histological lesions in the lungs of white mice infected with Aspergillus fumigatus by intraperitoneal injection, nasal implantation, the current research also examined an attempt to treat these tissue lesions by using both of the antifungal Amphotericin B and the alcoholic extract of Trametes for two weeks. The results showed that A. fumigatus led to tissue changes represented by the degeneration, desquamation the lining respiratory epithelium of the bronchiole, thickening, rupturing of the alveolar walls, congestion of the vessels and lymphocytic infiltration, the lungs of mice that infected with A. fumigatus and treated with the antifungal Amphotericin B and alcoholic extract of the Trametes spp. showed improvement, as degeneration and desquamation of the lining of the respiratory epithelium of the trachea, the presence of dust cells, lymphocytic infiltration, in addition to the appearance of semi-normal lung tissue in another histological also were observed. We conclude that Amphotericin B and alcoholic extract of Trametes spp. have activity in treating the histological lesions that resulted from A. fumigatus infection.
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